MLH1 polyclonal, anti-human, mouse, rat

Protein Family: Enzymes

Pathway and Disease: Cancers, Replication and Repair

Description:
DNA mismatch repair protein Mlh1 (MLH1) is involved in the repair of DNA mismatches. MLH1 is part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2, Turcot syndrome, Muir-Torre syndrome, including brain, colorectal, breast and endometrial tumors.

Alternate Names: DNA mismatch repair protein Mlh1, MutL protein homolog 1, MLH1, COCA2

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500

Accession No.: P40692

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human MLH1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by saturated sodium sulfate precipitation.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.