BLM polyclonal, anti-human, mouse

Protein Family: Enzymes

Pathway and Disease: Cancers, Replication and Repair

Description:
BLM, a helicase protein from the RecQ subfamily, participates in DNA replication and repair with a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. BLM is part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. Defects in BLM are the cause of bloom syndrome, characterized by growth deficiency, skin pigmentation disorders, predisposition to malignancy and chromosomal instability.

Alternate Names: Bloom syndrome protein, RecQ protein-like 3, DNA helicase RecQ-like type 2, BLM, RECQ2, RECQL3

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500

Accession No.: P54132, NP_000048

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human BLM.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.